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Which resin should I use ?
Which scavenger should I use ?
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RESIN GUIDE - Which resin should I use ?

If you are synthesizing long, complex or highly hydrophobic peptides, we highly recommend using ChemMatrix resins. This 100% PEG resin has demonstrated tremendous increase in purity and yield over polystyrene for these difficult peptides.

For peptide acid, we recommend the use of the HMPB-ChemMatrix resin
For peptide amide, we recommend the use of the PAL-ChemMatrix resin








Immobilized group
Obtained product
Cleavage conditions
Suggested resins*

R-COOH



R-CH2OH



Reductive



Merrifield Resin

Oxime Resin
  R-COOH

Strongly acidic

Mildly acidic

Nucleophilic



Merrifield Resin

Wang Resin

Benzhydryl Alcohol Resins

Trityl Alcohol Resin

Oxime Resin

Chloroacetyl Polystyrene

Mercaptomethyl Polystyrene
  R-COOCH3

Nucleophilic

Merrifield Resin

Oxime Resin
  R-CONH2

Nucleophilic

Strongly acidic


Merrifield Resin

Oxime Resin

BHA-HCI Resin

MBHA-HCI Resin

Aminomethyl Polystyrene
  R-CONHR'

Nucleophilic
(R'-NH2)

Oxime Resin
  R-OH

Reductive

Wang Resin

Mercaptomethyl Polystyrene
  R-CHO

Reductive

Mercaptomethyl Polystyrene

R-OH



R-OH



Strongly acidic

Mildly acidic





Merrifield Resin

Wang Resin

Trityl Chloride Resin

2-Chlorotrityl Chloride Resin

4-Methyltrityl Chloride Resin

Benzhydryl Chloride Resins

Benzhydryl Alcohol Resins

R-NCO



R'-NHCONH-R



Nucleophilic
(R'-NH2)



Oxime Resin

R-NH2



R-NH2



Mildly acidic



4-Alkoxybenzaldehyde Resin

Benzhydryl Chloride Resins

Trityl Chloride Resin

2-Chlorotrityl Chloride Resin

4-Methyltrityl Chloride Resin

R-SH



R-SH



Mildly acidic



Benzhydryl Chloride Resins

Trityl Chloride Resin

2-Chlorotrityl Chloride Resin

4-Methyltrityl Chloride Resin

Phenol



Phenol



Mildly acidic



Benzhydryl Chloride Resins

Trityl Chloride Resin

2-Chlorotrityl Chloride Resin

4-Methyltrityl Chloride Resin

Diol



Diol



Mildly acidic



Acetyl Polystyrene

Various



Cyclic
peptides



Various



Merrifield Resin

Wang Resin

Oxime Resin

   *Please note that only Matrix Innovation's resins are showed